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Natural Supplements with Evidence-based Benefits
BioCare Copenhagen offers a wide range of lactic acid bacteria strains (active ingredients), which can be used in food or food supplements.
Living Microorganisms
Lactic acid bacteria (probiotics) are living microorganisms, which reside in the gastrointestinal tract and play an essential role in digestion and immunity. Each strain has different characteristics and properties. Most strains have the ability to attach to and colonize on the mucosal membrane, which not only prevents pathogenic bacteria from colonizing and causing digestive upsets, but also reinforces the barrier function so the harmful bacteria and viruses cannot enter into the bloodstream and cause infection.
Approximately 80% of our immune system lies in the gastrointestinal tract, which is why lactic acid bacteria are essential for our immune system. Lactic acid bacteria help to enhance both non-specific and specific immune responses by increasing production of immune factors such as cytokines, immunoglobulins and interferon and by activating immunoreactive cells such as macrophages and lymphocytes.
Depending on the objective, specific strains might therefore be effective in suppressing allergies or autoimmune diseases, or in supporting the natural defense system against colds and flu. The beneficial bacteria also help to make our digestive system run smoothly and, amongst other things, to facilitate energy by producing enzymes that break down fats, carbohydrates and proteins. There are therefore many good reasons why consumers should take lactic acid bacteria on a daily basis even if they do not suffer from any digestive problems.
Biocare offers single bacteria as well as premixes, with documented efficacy.
Disclaimer: The information provided on this website should always be assessed in relation to compliance with the provisions of Regulation EC no 1924/2006 if the information is to be communicated to consumers within the European Union.
Maintain a healthy Intestine Flora
BioCare Copenhagen offers a range of yeast cells (active ingredients), which can be used in food or food supplements.
Yeast Strains
The probiotic yeast strain Saccharomyces cerevisiae var. boulardii has been shown to maintain and restore the flora in the large and small intestines and is therefore classified as a probiotic. Saccharomyces c. var. boulardii is a yeast strain which was originally isolated from lychee and mangosteen fruit in 1923 by the French scientist Henri Boulard. He observed that Southeast Asian natives chewed the skin of lychee and mangosteen to control symptoms of cholera and diarrhea.
Studies have demonstrated the antimicrobial and anti-toxin effects of S. c. var. boulardii and have shown that the strain helps to prevent pathogens adhering to the enterocytes, thus preserving a healthy endogenous flora. It also inhibits toxin receptor sites and hydrolyses bacterial toxins.
S. c. var. boulardii modulates the immune defense by stimulating secretory IgA and secretory components of immunoglobulins, which protect the intestinal mucosa from inflammation.
S. c. var. boulardii is one of the most effective probiotics to prevent antibiotic-associated diarrhea.
Another yeast strain, Saccharomyces cerevisiae derived from baker’s yeast, has shown promising results in alleviating symptoms of irritable bowel syndrome including significant reduction of the abdominal/bowel pain and discomfort.
Disclaimer: The information provided on this website should always be assessed in relation to compliance with the provisions of Regulation EC no 1924/2006 if the information is to be communicated to consumers within the European Union.
Long-term Immune Stimulation
BioCare Copenhagen offers a wide range of microbial lysates (active ingredients), which can be used in food or food supplements.
Immunogens from Inactivated Bacteria
Microbial lysates are harmless bacterial antigens derived from different inactivated bacterial species and can be characterized as natural immunomodulators. The antigens are obtained from a mass culture of reference bacterial strains, using mechanical lysis of cells and lyophilization.
The bacterial antigens are able to activate monocytic macrophagic cells of the submucosa, inducing differentiation through immature dendritic cells and their maturation in mature dendritic cells. The activation of such a mechanism triggers a suitable stimulation of the immune response.
The bacterial lysate is both a specific and non-specific immunostimulating agent, indicated for the prevention and treatment of respiratory infections, paradontosis, bacterial vaginosis or urinary tract infections.
Probiotics usually work fast and the bacteria only stay in the system for a relatively short period, e.g. 3-4 weeks, and will therefore not offer any long-term effect without a continuous intake. Microbial lysates, on the other hand, may not work as fast, but they offer a long-term effect.
Disclaimer: The information provided on this website should always be assessed in relation to compliance with the provisions of Regulation EC no 1924/2006 if the information is to be communicated to consumers within the European Union.
Tyndalized bacteria are heat killed lactic acid bacteria that can be used very effectively to treat bacterial infections and intestinal upsets, since they do not rely on cell growth in the intestine, at a time when the intestinal conditions for growth may not be optimal.
Although the bacteria are dead, they still demonstrate an antagonistic effect against invasive pathogens in the intestine by increasing immune activity.
The tyndalized lactic acid bacteria inhibit pathogen bacteria due to:
- stimulation of the immune response by;
- - increased TNF-α production
- - nitric oxide release
- - increased phagocytic activity in macrophages
- adhesion to enterocytes, which prevent pathogenic bacteria from colonizing and entering into the blood stream
- Residual bacteriocins from the cell culture which have a bacteriostatic activity and bacteriocidal effect on specific pathogenic bacteria
SUPPORTED BY SCIENCE
BIOCARE COPENHAGEN’S SCIENTIFIC ADVISORY BOARD is an essential support in our clinical research and development of probiotic ingredients. The board is comprised of some of Denmark’s leading experts within probiotics and gastrointestinology, including:
Michael Tvede, M.D.
Arne Astrup,
Dr. Erik Lindblad
MICHAEL TVEDE
MD.
ARNE ASTRUP
DR.
Erik Lindblad
DR.
Dr. Lindblad is a specialist in Vaccines and Adjuvants. He has published several papers on vaccines and among others he has been a member of The International Editorial Board of the journal VACCINE. Elsevier; Chairman of the European Adjuvant Advisory Committee (EAAC) etc.
ABOUT BIOCARE COPENHAGEN
BASED ON HOSPITAL RESEARCH
BioCare Copenhagen is a Danish bioscience company that specializes in microbial actives targeting gastrointestinal disorders, metabolism, infections and immunity.
The company’s activities are based on research conducted at the Copenhagen University Hospital, Denmark’s leading hospital for patients requiring highly specialized treatment. BioCare Copenhagen was established as a joint venture between the Danish Ministry of Science, Technology and Innovation and the management team Søren B. Thomsen (CEO) and Jesper Gantzel (COO).
Biocare Copenhagen was acquired by Royal DSM in December 2017.
DSM is a global science-based company active in health, nutrition and materials. The company and its associated companies deliver annual net sales of about € 10 billion with approximately 25.000 employees and is listed at the Amsterdam Stock Exchange (Euronext NYSE) with a market capitalization of currently over EUR 12 billion.
DSM is a continuous leader in the Dow Jones Sustainability Index and the company have just been awarded the #2 position in Fortune’s “Change the World List”.
DSM is the world’s biggest provider of nutritional solutions for human and animal nutrition and is among others a leading supplier of vitamins, omega’s, carotenoids, nutritional premixes etc. and aim to become a key player within Gut Health Solutions offering a wide range of products in within probiotics, prebiotics, enzymes etc.
The company has enjoyed rapid and significant international growth, offering white-label food supplements and medical devices. BioCare Copenhagen has multi-market distribution agreements with a number of leading pharmaceutical companies and has launched products in over 46 countries worldwide. The products are manufactured at state-of-the-art facilities in the EU complying with GMP, ISO & HACCP regulations.
Offering innovative products with a strong competitive edge, BioCare Copenhagen and its partners have gained a strong foothold in several European markets, including the Danish domestic market, reaching a market share of 70% in probiotic supplements. Furthermore, the company was awarded the Danish Gazelle price 2016 due to its continuous growth in the preceding four years.
A PERFECT BLEND OF EXPERIENCE AND SCIENCE
Our management team, which consists of Søren B. Thomsen (CEO) and Jesper Gantzel (COO) has a successful track record within the industry in developing and launching innovative supplement concepts on a pan-european scale. The combination of solid commercial competences and scientific support from leading doctors and gastrointestinal experts in our Scientific Advisory Board, have formed a solid basis for a number of novel and unique food supplement concepts.
CHAIRMAN OF THE BOARD JEREMY (JINGHUAI) XU is President, Human Nutrition & Health for DSM Nutritional Products headquartered near Basel, Switzerland.
Jeremy holds a Bachelor’s degree in Biology and Biomedical Engineering from Zhejiang University of China, a Ph.D. in Molecular biology and Biochemistry from Purdue University, USA, and an MBA from the Krannert Scholl of Management.
Jeremy is an experienced business leader with a strong track record of delivering results and leading multinational teams.
BOARD MEMBER SAIDA MADJITOVA is Vice President Finance Global Human Nutrition & Health at DSM.
Saida has had a successful international career in Finance. She worked with both multinational corporations and private equity owned businesses. Next to Commercial and Operations Finance, she has extensive experience in M&A, integration and establishing standalone entities. Saida holds BSc from Stockholm School of Economics in Riga and an MBA from Willamette University.
BOARD MEMBER MAHA EL KHARBOTLY is Global Vice President HNH Specialty Nutrition, Switzerland.
Maha holds a batchelor degree in in Economics and MBA from Gies College of Business. She is a senior Executive with a broad background in Marketing & Sales and has international working experience having lived and worked in the US, Germany and the UK. She build her career in marketing & sales with Whirlpool and GROHE. Before joining DSM, Maha was CMO of LIXIL Water Technology Americas.
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